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Malaria – where the risk is, and how to avoid it

Malaria in South Africa is limited to specific areas and seasons, but any fever after visiting one is malaria until proven otherwise. Where, when, and what to do.

Where and when

Malaria in South Africa is confined to the low-lying north-east of the country: the border areas of Limpopo and Mpumalanga — including the Kruger National Park — and the far north-east of KwaZulu-Natal. The rest of the country, including all the major cities, is not a malaria area.

Transmission is seasonal, broadly from the start of the rains in spring through to autumn, with the highest risk in the late summer months. Neighbouring Mozambique, Zimbabwe and parts of Botswana carry higher and more year-round risk, which matters for anyone travelling on.

Avoiding bites is the main defence

The mosquito that transmits malaria bites between dusk and dawn, which is what makes the precautions below effective and specific.

  1. Use an insect repellent containing DEET or picaridin on exposed skin from late afternoon onwards, and reapply as directed.
  2. Wear long sleeves and long trousers after dark, in light colours.
  3. Sleep under an insecticide-treated net if the room is not sealed and air-conditioned.
  4. Use a plug-in insecticide or a mosquito coil in the room at night.
  5. Keep windows and doors screened, and closed after dark.
  6. Apply sunscreen first and repellent over it, not the other way round.

Preventive tablets

For travel into a risk area during the transmission season, preventive medication is usually recommended alongside bite avoidance rather than instead of it. Which one suits you depends on the destination, your other medicines, pregnancy and how long you are going for.

Used for prevention or treatment in South Africa, all on medical advice:

  • Doxycycline Doximal, Cyclidox, Adco-Doxycycline, Vibramycin

    STIs (chlamydia, syphilis); atypical pneumonia; malaria prophylaxis; tick bite fever; acne (low dose)

  • Artemether-Lumefantrine (AL) Coartem

    Uncomplicated Plasmodium falciparum malaria

  • Quinine Quinine Sulphate, Qualaquin

    Severe malaria (IV); uncomplicated falciparum malaria (when ACTs unavailable); nocturnal leg cramps

  • Prophylaxis must be started before travel, taken throughout, and continued for the full period after leaving — stopping on the way home is a common and dangerous mistake.
  • No preventive tablet is completely effective, which is why bite avoidance still matters.
  • Pregnant women and small children are at much higher risk of severe malaria. Ideally avoid travel to risk areas; if that is not possible, get specific advice well beforehand.
  • Speak to a travel clinic or pharmacist a few weeks before travelling, not the day before.

Recognising it, and acting fast

Early malaria looks exactly like flu: fever, chills, sweating, headache, muscle aches, tiredness, sometimes nausea, vomiting or diarrhoea. There is nothing distinctive about it, which is the whole problem.

It can progress from mild to life-threatening within a day, particularly in children, pregnant women and anyone without previous exposure. A rapid test takes minutes and is available at clinics in and around risk areas.

Common questions

Is Johannesburg or Cape Town a malaria area?
No. Malaria transmission in South Africa is limited to low-lying parts of Limpopo, Mpumalanga and north-eastern KwaZulu-Natal. Cases seen in the cities are almost always in people who travelled.
I grew up in a malaria area. Am I immune?
Partial immunity develops with repeated exposure but fades within a year or two of leaving. People who move to a city and return to visit family are a well-recognised high-risk group precisely because they believe they are still protected.
Can I skip the tablets if I use repellent properly?
Bite avoidance is essential but not complete, and a single bite is enough. For travel into a risk area in season, take medical advice rather than choosing one or the other yourself.

Sources

Last reviewed 4 August 2026.