Anaphylaxis – recognising a severe allergic reaction
How to tell a severe allergic reaction from a mild one, how to use an adrenaline auto-injector, and why every case needs an ambulance even after it improves.
Telling severe from mild
Most allergic reactions are mild: a rash, hives, itching, a runny nose, some swelling. Anaphylaxis is different. It involves the breathing or the circulation, it can develop within minutes, and it can kill.
- 10177Emergency Medical Services
- 10111South African Police Service
- 112Universal Emergency (mobile)
- 0800 029 999SADAG Mental Health Crisis Line
- 0861 554 911Poisons Information Helpline
- Common triggers are foods such as peanuts, tree nuts, shellfish, eggs, milk and sesame; insect stings; medicines, especially some antibiotics and anti-inflammatories; and latex.
- A previous mild reaction does not predict a mild next one. Someone can react mildly for years and then have anaphylaxis.
What to do
- Use the adrenaline auto-injector immediately if there is one. Do not wait to see whether it gets worse — adrenaline given early is what works, and giving it when it turns out not to be needed does far less harm than delaying.
- Call an ambulance and say the word anaphylaxis.
- Lie the person flat with their legs raised. If they are struggling to breathe, let them sit up. If they are pregnant, lie them on their left side. If unconscious but breathing, roll them onto their side.
- Do not stand them up or let them walk, even if they feel better. Standing suddenly can cause the circulation to collapse.
- If there is no improvement after five minutes and a second auto-injector is available, use it.
- Stay with them until the ambulance arrives, and take the used injector and the suspected trigger with them.
An auto-injector is used into the outer thigh muscle, and it works through clothing. Follow the instructions on the device itself — hold it in place for the time the device specifies, then rub the area.
Adrenaline is the treatment for anaphylaxis. Antihistamines and steroids are for mild reactions or given afterwards, and are NOT a substitute:
Adrenaline (Epinephrine) Auto-injector — EpiPen, Jext
Anaphylaxis (emergency treatment)
Cetirizine — Zyrtec, Texa, Adco-Cetirizine, Allerclear
Allergic rhinitis; urticaria; allergic conjunctivitis
Prednisone — Trolic, Meticorten, Adco-Prednisone, Panafcort
Asthma exacerbations; COPD exacerbations; inflammatory and autoimmune conditions
Why hospital is not optional
Symptoms can return hours after they seem to have settled, once the adrenaline wears off. Everyone who has had anaphylaxis needs to be observed in hospital even if they feel completely well again by the time help arrives.
- Ask for a replacement auto-injector before you leave, and check the expiry date on the ones you keep.
- Ask for referral to work out what caused it, if it is not obvious.
- Carry two auto-injectors rather than one, and keep them with the person rather than in a car or a cupboard.
- Tell school, work or family where they are and how to use them — the person having the reaction is often not able to.
- Wear or carry something that names the allergy.
Common questions
- What are the signs of anaphylaxis?
- Difficulty breathing or wheezing, a hoarse voice or tight throat, swelling of the tongue, lips or throat, feeling faint or collapsing, or sudden severe abdominal pain after a sting or food. Any one of them means use adrenaline and call an ambulance.
- Can antihistamines treat a severe allergic reaction?
- No. They help a rash but do nothing for a closing airway or collapsing circulation. Reaching for an antihistamine instead of adrenaline is a recognised cause of death in anaphylaxis.
- Do I still need hospital if the auto-injector worked?
- Yes, always. Symptoms can return hours later as the adrenaline wears off, so everyone who has had anaphylaxis needs to be observed in hospital even if they feel completely well.
Sources
- Basic life support and resuscitation guidelinesResuscitation Council of Southern Africa
- Adult Hospital Level Standard Treatment Guidelines and Essential Medicines ListNational Department of Health, South Africa
- Medicines Online Directory and approved patient information leafletsSouth African Health Products Regulatory Authority
- Clinical and public health guidanceWorld Health Organization
Last reviewed 11 August 2026.